反应详情

5 g of erythromycin A and 4.7 g of sodium acetate (×3 H2O) were dissolved in 200 ml of an 8:2 methanol/water mixture. 1.75 g of iodine were added to the solution, and the reaction mixture was then irradiated with a quartz lamp at room temperature for 20 minutes. Subsequently, half the solvent was evaporated, and the remaining reaction mixture was poured into a mixture of 140 ml of water and 10 ml of ammonia. The reaction mixture was extracted three times with 20 ml portions of methyl t-butyl ether. The ether extract was separated and some of the ether was evaporated. The reaction product was then left to crystallize out and was recrystallized from acetone. 2 g of N-demethylerythromycin A were obtained.

1. customthe reaction mixture was then irradiated with a quartz lamp at room temperature for 20 minutes
2. customSubsequently, half the solvent was evaporated
3. customthe remaining reaction mixture
4. extractionThe reaction mixture was extracted three times with 20 ml portions of methyl t-butyl ether
5. extractionThe ether extract
6. customwas separated
7. customsome of the ether was evaporated
8. waitThe reaction product was then left
9. customto crystallize out
10. customwas recrystallized from acetone