反应详情

温度

70 °C

To 1 ml of methanol were added 500 mg of 2-amino-3,5,6-trifluoropyridine together with 800 mg of 28% sodium methoxide/methanol solution, and the mixture was stirred at 70° C. for 3 and half hours, and allowed to cool. After adding 25 ml of chloroform, the mixture was washed with 5 ml of distilled water. The chloroform layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain the title product.

1. temperatureto cool
2. washthe mixture was washed with 5 ml of distilled water
3. dry with materialThe chloroform layer was dried over anhydrous magnesium sulfate
4. concentrationconcentrated under reduced pressure