HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 368439Generated: October 29, 2026
Dimethylformamide → 7-[3-(Ethylamino)azetidin-1-yl]-1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
https://huagongshe.com/reaction/368439
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-Methylpyrrolidine | HCID 8454 | — |
| Reactant | 1-(6-Amino-3,5-difluoro-2-pyridinyl)-8-chloro-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 15434901 | — |
| Reactant | N-ethylazetidin-3-amine dihydrochloride | HCID 22121198 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 7-[3-(Ethylamino)azetidin-1-yl]-1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 12135031 | 88.7% |
Reaction Steps
To 310 mg of N,N-dimethylformamide were added 100 mg of 1-(6-amino-3,5-difluoropyridine-2-yl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, 70 mg of 3-(ethylamino)azetidine dihydrochloride, and 150 mg of N-methylpyrrolidine, and the mixture was stirred at 90° C. for 15 minutes. After adding 1 ml of ethanol, the mixture was allowed to cool, and the precipitate was collected by filtration and washed with ethanol and diisopropylether successively to obtain 107 mg of the title compound as a colorless powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06133284 |
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| Source dataset | uspto-grants-2000_10 |
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| ORD ID | ord-d76f628476b24a7ba9f4bf5026859734 |
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| Source note | uspto-grants-2000_10 |
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