HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 368441Generated: October 29, 2026
Dimethylformamide → HCID 22121206, compound
https://huagongshe.com/reaction/368441
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-Methylpyrrolidine | HCID 8454 | — |
| Reactant | 1-(6-Amino-3,5-difluoro-2-pyridinyl)-8-chloro-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 15434901 | — |
| Reactant | 1-(Azetidin-3-yl)methanamine--hydrogen chloride (1/2) | HCID 22121283 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 22121206 | HCID 22121206 | 44.8% |
Reaction Steps
To 280 mg of N,N-dimethylformamide were added 80 mg of 1-(6-amino-3,5-difluoropyridine-2-yl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, 100 mg of 3-(aminomethyl)azetidine dihydrochloride, and 200 mg of N-methylpyrrolidine, and the mixture was stirred at 90° C. for 25 minutes. After adding 0.5 ml of ethanol, the mixture was allowed to cool, and the precipitate was collected by filtration and washed with ethanol and diisopropylether successively to obtain 42 mg of the title compound as a colorless powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06133284 |
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| Source dataset | uspto-grants-2000_10 |
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| ORD ID | ord-6f7e6aab70904f2d85ebb3376638cfc7 |
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| Source note | uspto-grants-2000_10 |
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