Ethyl 1-(6-amino-3,5-difluoropyridin-2-yl)-5-benzylamino-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate → Ethyl 5-amino-1-(6-amino-3,5-difluoropyridin-2-yl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

HRID 368503Notes

Reaction equation

HRID 368503 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[C:17]3[C:12](=[C:13]([NH:21]CC4C=CC=CC=4)[C:14]([F:20])=[C:15]([F:19])[C:16]=3[F:18])[C:11](=[O:29])[C:10]([C:30]([O:32][CH2:33][CH3:34])=[O:31])=[CH:9]2)[C:5]([F:35])=[CH:4][C:3]=1[F:36]>[Pd].C(O)(=O)C>[NH2:21][C:13]1[C:14]([F:20])=[C:15]([F:19])[C:16]([F:18])=[C:17]2[C:12]=1[C:11](=[O:29])[C:10]([C:30]([O:32][CH2:33][CH3:34])=[O:31])=[CH:9][N:8]2[C:6]1[C:5]([F:35])=[CH:4][C:3]([F:36])=[C:2]([NH2:1])[N:7]=1

Participants

4

Reactant 1

HCID 22121167Ethyl 1-(6-amino-3,5-difluoropyridin-2-yl)-5-benzylamino-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Product 1

HCID 22121240Ethyl 5-amino-1-(6-amino-3,5-difluoropyridin-2-yl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylateYield 74.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

To 5 ml of acetic acid was added 260 mg of ethyl 1-(6-amino-3,5-difluoropyridine-2-yl)-5-benzylamino-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate together with 50 mg of 10% palladium on carbon, and the mixture was hydrogenated at room temperature for 4 hours. The catalyst was separated by filtration, and the solvent and the like were distilled off under reduced pressure. The procedure of adding 10 ml of ethanol to the residue and concentrating under reduced pressure was repeated twice. The precipitate was dispersed in ethanol, collected by filtration, and washed with ethanol and diisopropylether successively to obtain 160 mg of the title compound as a pale yellow powder.

Workup

  1. customThe catalyst was separated by filtration
  2. distillationthe solvent and the like were distilled off under reduced pressure
  3. additionThe procedure of adding 10 ml of ethanol to the residue
  4. concentrationconcentrating under reduced pressure
  5. additionThe precipitate was dispersed in ethanol
  6. filtrationcollected by filtration
  7. washwashed with ethanol and diisopropylether successively

Sources & evidence

ORD record
ord-ccdc16eb951d496f823f7b642f9dada7
Source dataset
uspto-grants-2000_10
Patent number
US06133284

Reaction notes

Loading…