Methyl iodide → HCID 18630378, compound

HRID 368591Notes

Reaction equation

HRID 368591 reaction equation
[CH2:1]([N:3]([CH2:17][CH3:18])[C:4](=[S:16])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:6]=1[Si:12]([CH3:15])([CH3:14])[CH3:13])[CH3:2].[CH3:19]I>>[CH2:17]([N:3]([CH2:1][CH3:2])[C:4](=[S:16])[C:5]1[CH:10]=[CH:9][C:8]([CH3:19])=[C:7]([F:11])[C:6]=1[Si:12]([CH3:13])([CH3:15])[CH3:14])[CH3:18]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 18630176HCID 18630176, compound

Product 1

HCID 18630378HCID 18630378, compound

Procedure

The title compound was prepared from the compound of Example 74 and 3.0 eq MeI according to General Method A and recrystallized from cold hexanes/ethyl acetate to give 2.5 g of the title compound, an 82% yield. m.p. 96-97° C.

Workup

  1. customrecrystallized from cold hexanes/ethyl acetate

Sources & evidence

ORD record
ord-220ff170fa4843edb70399965d9b9325
Source dataset
uspto-grants-2000_10
Patent number
US06133252

Reaction notes

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