Methyl iodide → HCID 18630005, compound

HRID 368613Notes

Reaction equation

HRID 368613 reaction equation
[CH2:1]([N:3]([CH2:16][O:17][CH3:18])[C:4](=[O:15])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Si:11]([CH3:14])([CH3:13])[CH3:12])[CH3:2].[CH3:19]I>>[CH2:1]([N:3]([CH2:16][O:17][CH3:18])[C:4](=[O:15])[C:5]1[C:6]([Si:11]([CH3:13])([CH3:12])[CH3:14])=[CH:7][CH:8]=[CH:9][C:10]=1[CH3:19])[CH3:2]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 18630303HCID 18630303, compound

Product 1

HCID 18630005HCID 18630005, compound

Procedure

The compound of Example 50 (1.33 g, 5.0 mmol) and MeI (2.8 g, 20 mmol) were combined according to General Method B. The resulting reaction was partitioned between ethyl acetate and sat aq NaHCO3. The organic phase was washed with brine, dried (MgSO4), and concentrated to afford a quantitative yield of the title compound as an oil.

Workup

  1. customThe resulting reaction
  2. customwas partitioned between ethyl acetate
  3. washThe organic phase was washed with brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-0d1400b3fa674b63a339220629478a68
Source dataset
uspto-grants-2000_10
Patent number
US06133252

Reaction notes

Loading…