HuagongsheHuagongshe Chemistry Print Report · For research reference only
Uridine → 2'-O-Methyluridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Uridine | HCID 6029 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Dibutyltin oxide | HCID 61221 | — |
| Reactant | 2',3'-O-dibutylstannyleneuridine | HCID 131720090 | — |
| Product | 2'-O-Methyluridine | HCID 102212 | — |
Reaction Steps
As per the procedure of Example 49, uridine (8.5 g) was treated with dibutyl tin oxide (8.2 g, 1 eq). The resulting 2',3'-O-dibutylstannylene uridine was treated with iodomethane (16 ml) at 42° C. as per Example 50 to give a mixture of the 2' and 3' alkylated products (3.5 g) as a foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06133438 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-d45a3b863b0349219c34c3ad7d24588f |
| Source note | uspto-grants-2000_10 |