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HRID368724

反应详情

EQUATION

反应方程式

HRID 368724 的结构方程式

REACTANTS

反应物

4
结构：O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1
HCID6029

Uridine

C9H12N2O6

结构：CCCCCCCCCI
HCID20275

1-Iodononane

C9H19I

结构：CCC[CH2][Sn](=[O])[CH2]CCC
HCID61221

Dibutylstannane oxide

C8H18OSn

结构：CCCCO[C@@H]1[C@@H]([C](O)=[SnH2])O[C@@H](n2ccc(=O)[nH]c2=O)[C@@]1(O)CCCC
HCID131720090

未命名化合物

PRODUCTS

生成物

1
结构：CCCCCCCCCO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1ccc(=O)[nH]c1=O
HCID22874743

未命名化合物

PROCEDURE

实验过程

As per the procedure of Example 49, uridine (22.5 g) was treated with dibutyl tin oxide (22.5 g, 1 eq). The resulting 2',3'-O-dibutylstannyleneuridine was treated with iodononane (11 ml, 1.3 eq.) at 130-140° C. as per Example 50 to give the 2' and 3' isomers (11.2 g) as an oil.

WORKUP

后处理

  1. customto give the 2' and 3' isomers (11.2 g) as an oil