HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cytidine → 2'-O-Nonylcytidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cytidine | HCID 6175 | — |
| Reactant | 1-Iodononane | HCID 20275 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2'-O-Nonylcytidine | HCID 22868393 | — |
Reaction Steps
Cytidine (10.1 g, 0.0415 mol), sodium hydride (2.0 g, 1.2 eq), iodononane (9.8 ml, 1.2 eq.) in DMF (100 ml) were reacted as per the procedure of Example 71, Step 1 to yield the 2' and 3' isomers as a sticky foam (11.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06133438 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-f45fe0de1f704c428b0d60062018bdb3 |
| Source note | uspto-grants-2000_10 |