N4-Benzoyl-2'-O-propylcytidine → HCID 69941629, compound

HRID 368733Notes

Reaction equation

[C:1]([NH:9][C:10]1[CH:27]=[CH:26][N:13]([C@@H:14]2[O:25][C@H:22]([CH2:23][OH:24])[C@@H:20]([OH:21])[C@H:15]2[O:16][CH2:17][CH2:18][CH3:19])[C:12](=[O:28])[N:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:29][O:30][C:31]1[C:32]([O:51][CH3:52])=[C:33]([CH:48]=[CH:49][CH:50]=1)[C:34](Cl)([C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>>[C:1]([NH:9][C:10]1[CH:27]=[CH:26][N:13]([C@@H:14]2[O:25][C@H:22]([CH2:23][O:24][C:34]([C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)([C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=3)[C:33]3[CH:48]=[CH:49][CH:50]=[C:31]([O:30][CH3:29])[C:32]=3[O:51][CH3:52])[C@@H:20]([OH:21])[C@H:15]2[O:16][CH2:17][CH2:18][CH3:19])[C:12](=[O:28])[N:11]=1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 22874774N4-Benzoyl-2'-O-propylcytidine

HCID 66624882Dimethoxytrityl chloride

Product 1

HCID 69941629HCID 69941629, compoundYield 49%

Procedure

N4-Benzoyl-2'-O-propylcytidine (3.0 g, 0.007 mol) was treated with dimethoxytrityl chloride (1.5 g) as per the procedure of Example 72 to give 1.5 g of pure product. Anal. Calcd. for C40H42N3O8.1/2H2O: C, 68.45; H, 6.18; H, 5.99. Found: C, 68.39; H, 5.99; N, 5.95.

Sources & evidence

ORD record: ord-7954af429100408daee774284cf4af04
Source dataset: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06133438

Reaction notes

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