反应详情

To 1.5 l of diethyl ether was added 12.63 g (33.67 mmol) of 3-bromo-3,4-dihydro-2,2-dimethyl-6-pentafluoroethyl-2H-1-benzopyran-4-ol synthesized according to the process of JP-B-2-237985, and 30.2 g of potassium hydroxide was added thereto, followed by stirring at room temperature for 54 hours. The insoluble material was removed by filtration, and the solvent was removed by distillation under reduced pressure to yield 9.5 g (96.2%) of 3,4-dihydro-2,2-dimethyl-3,4-epoxy-6-pentafluoroethyl-2H-1-benzopyran.

1. customsynthesized
2. additionwas added
3. customThe insoluble material was removed by filtration
4. customthe solvent was removed by distillation under reduced pressure