1-Piperazinecarboxylic acid, anhydride with acetic acid → HCID 23288675, compound

HRID 368769Notes

Reaction equation

HRID 368769 reaction equation
[OH:1][CH:2]([CH2:35][OH:36])[CH2:3][O:4][C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([NH:23][S:24]([C:27]2[CH:32]=[CH:31][C:30]([S:33][CH3:34])=[CH:29][CH:28]=2)(=[O:26])=[O:25])[C:13]=1[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH3:22])[CH:16]=1)[C:8](O)=[O:9].[C:37]([O:40][C:41]([N:43]1[CH2:48][CH2:47][NH:46][CH2:45][CH2:44]1)=[O:42])(=O)[CH3:38]>>[OH:1][CH:2]([CH2:35][OH:36])[CH2:3][O:4][C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([NH:23][S:24]([C:27]2[CH:32]=[CH:31][C:30]([S:33][CH3:34])=[CH:29][CH:28]=2)(=[O:25])=[O:26])[C:13]=1[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH3:22])[CH:16]=1)[C:8]([N:46]1[CH2:45][CH2:44][N:43]([C:41]([O:40][CH2:37][CH3:38])=[O:42])[CH2:48][CH2:47]1)=[O:9]

Participants

3

Reactant 2

HCID 187650611-Piperazinecarboxylic acid, anhydride with acetic acidHCID 23288711HCID 23288711, compound

Product 1

HCID 23288675HCID 23288675, compound

Procedure

In analogy to Example 121, by coupling 3-(2,3-dihydroxy-propoxy)-4-(3-methoxy-phenoxy)-5-(4-methylsulphanyl-benzenesulphonylamino)-benzoic acid with 1-acetoxycarbonylpiperazine there was obtained ethyl 4-[3-(2,3-dihydroxy-propoxy)-4-(3-methoxy-phenoxy)-5-(4-methylsulphanylbenzenesulphonylamino)-benzoyl]-piperazine-1-carboxylate as a white foam.

Sources & evidence

ORD record
ord-0ed5d71bd902423ea28b8b6098876ede
Source dataset
uspto-grants-2000_10
Patent number
US06133442

Reaction notes

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