Morpholine → HCID 23288627, compound

HRID 368771Notes

Reaction equation

[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([NH:23][S:24]([C:27]2[CH:32]=[CH:31][C:30]([S:33][CH3:34])=[CH:29][CH:28]=2)(=[O:26])=[O:25])[C:13]=1[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH3:22])[CH:16]=1)[C:8](O)=[O:9].[NH:35]1[CH2:40][CH2:39][O:38][CH2:37][CH2:36]1>>[OH:1][CH2:2][CH2:3][O:4][C:5]1[C:13]([O:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH3:22])[CH:16]=2)=[C:12]([NH:23][S:24]([C:27]2[CH:32]=[CH:31][C:30]([S:33][CH3:34])=[CH:29][CH:28]=2)(=[O:25])=[O:26])[CH:11]=[C:7]([C:8]([N:35]2[CH2:40][CH2:39][O:38][CH2:37][CH2:36]2)=[O:9])[CH:6]=1

Participants

Reactant 2

HCID 8083Morpholine

HCID 17878580HCID 17878580, compound

Product 1

HCID 23288627HCID 23288627, compound

Procedure

In analogy to Example 121, by coupling 3-(2-hydroxy-ethoxy)-4-(3-methoxy-phenoxy)-5-(4-methylsulphanyl-benzenesulphonylamino)-benzoic acid with morpholine there was obtained N-[3-(2-hydroxy-ethoxy)-2-(3-methoxy-phenoxy)-5-(morpholine-4-carbonyl)-phenyl]-4-methylsulphanyl-benzenesulphonamide.

Sources & evidence

ORD record: ord-7fe421baf9404bc3a8e2361a59682e74
Source dataset: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06133442

Reaction notes

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