4-t-Butylbenzenesulfonyl chloride → HCID 23288576, compound

HRID 368776Notes

Reaction equation

HRID 368776 reaction equation
[CH2:1]([O:4][C:5]1[CH:6]=[C:7]([CH:10]=[C:11]([NH2:22])[C:12]=1[O:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=1)[C:8]#[N:9])[CH:2]=[CH2:3].[C:23]([C:27]1[CH:32]=[CH:31][C:30]([S:33](Cl)(=[O:35])=[O:34])=[CH:29][CH:28]=1)([CH3:26])([CH3:25])[CH3:24]>>[CH2:1]([O:4][C:5]1[C:12]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=2)=[C:11]([NH:22][S:33]([C:30]2[CH:31]=[CH:32][C:27]([C:23]([CH3:26])([CH3:25])[CH3:24])=[CH:28][CH:29]=2)(=[O:35])=[O:34])[CH:10]=[C:7]([C:8]#[N:9])[CH:6]=1)[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 1398824-t-Butylbenzenesulfonyl chlorideHCID 23288592HCID 23288592, compound

Product 1

HCID 23288576HCID 23288576, compound

Procedure

Analogously to Example 143e), from 3-allyloxy-5-amino-4-(3-methoxy-phenoxy)-benzonitrile by coupling with 4-tert-butylbenzenesulphonyl chloride there was obtained N-[3-allyloxy-5-cyano-2-(3-methoxy-phenoxy)-phenyl]-4-tert-butyl-benzenesulphonamide as a crystalline solid.

Sources & evidence

ORD record
ord-0ac4cde4021c4d30a643f5d55c6ef3e8
Source dataset
uspto-grants-2000_10
Patent number
US06133442

Reaction notes

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