Trifluoroacetic acid → HCID 178520538, compound

Participants

Reaction Steps

5-[1-benzyl-3-(3,4-dichlorophenyl)-3-oxo-propyl]-1(4-methoxybenzyl)-1H-tetrazole (1.6 g, 3.3 mmol), from the previous step) and TFA (20 ml) were mixed and stirred at room temperature under nitrogen atmosphere for 40 hours. The mixture was diluted with water (100 ml) and extracted with methylene chloride (3×200 ml). The organic layers were combined, washed with water (2×100 ml), brine (1×100 ml) and dried over anhydrous sodium sulphate. The solvent was removed under vacuum and the residue was flash chromatographed by using cyclohexane/ethyl acetate 0÷20 as eluent. The title compound was obtained as a colourless solid (0.6 g, 50%) (m.p. 172°-174° C.).

Provenance & Evidence