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Hydrogen Bromide → 4-Chloro-2-fluorobenzyl bromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | Hydrogen Peroxide | HCID 784 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Azobisisobutyronitrile | HCID 6547 | — |
| 反応物 | 4-Chloro-2-fluorotoluene | HCID 520630 | — |
| 溶媒 | Chlorobenzene | HCID 7964 | — |
| 生成物 | 4-Chloro-2-fluorobenzyl bromide | HCID 2736551 | — |
反応手順
361.5 g of 4-chloro-2-fluorotoluene, 520 g of chlorobenzene, 6 g of conc. H2SO4, 467 g of 47% strength hydrobromic acid and 2.7 g of 2,2'-azobis(2-methylpropionitrile) were mixed at 70° C. in a 4 l stirred apparatus. 620.5 g of a 10% strength aqueous hydrogen peroxide solution and a solution of 16.5 g of 2,2'-azobis(2-methylpropionitrile) in 270 g of chlorobenzene were simultaneously added dropwise over the course of 1.5 hours. The mixture was then stirred at 70° C. for 1 hour. GC analysis of the org. phase:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06133468 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-53fa43640059453fb01ab66a7d352236 |
| 出典メモ | uspto-grants-2000_10 |