反应详情

Ethyl 2-methyl-2-phenylpropionate (XXXVIII, 4.50 g, 23.5 mmol) is added to lithium aluminum hydride (0.908 g, 23.5 mmol) in dry ether (100 ml) cooled at 0°. After stirring for 2.5 hr, the mixture is quenched by adding, successively, water (1 ml), aqueous sodium hydroxide (15%, 1 ml) and water (3 ml). After stirring for several minutes, the solids are filtered off and washed well with ether. The filtrate is washed twice with saline and the organic phase is separated, dried over magnesium sulfate and concentrated to give 2-methyl-2-phenylpropanol (XLV), NMR (CDCl3) 1.34, 3.62, 3.71, 7.22 and 7.31-7.41 δ.

1. temperaturecooled at 0°
2. customthe mixture is quenched
3. additionby adding
4. stirringAfter stirring for several minutes
5. filtrationthe solids are filtered off
6. washwashed well with ether
7. washThe filtrate is washed twice with saline
8. customthe organic phase is separated
9. dry with materialdried over magnesium sulfate
10. concentrationconcentrated