1-(3-Chlorophenyl)piperazine dihydrochloride → 1-(3-Chlorophenyl)-4-[2-(isochroman-1-yl)ethyl]piperazine dihydrochloride

Participants

Role	Name	HCID	Charge
Reactant	1-(3-Chlorophenyl)piperazine dihydrochloride	HCID 11957487	—
Reactant	1-[2-(Isochroman-1-yl)ethyl]-4-(2-methoxyphenyl)piperazine dihydrochloride monohydrate	HCID 23288951	—
Product	1-(3-Chlorophenyl)-4-[2-(isochroman-1-yl)ethyl]piperazine dihydrochloride	HCID 23288780	—

Reaction Steps

Following the general procedure of EXAMPLE 1 and making non-critical variations but using 1-(3-chlorophenyl)piperazine dihydrochloride (XI, 0.5169 g (1.92 mmol) in place of 1-(2-chlorophenyl)piperazine dihydrochloride (XI), the title compound is obtained, mp 176.75-179°; MS (m/z) 356; IR (mineral oil) 2269, 2295, 2166, 2130, 2200 and 1449 cm-1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06133446
Source dataset	uspto-grants-2000_10
ORD ID	ord-7675d92144fb4f9ebc278ad9d22096b5
Source note	uspto-grants-2000_10