HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane methanol → 1-[2-(Isochroman-1-yl)ethyl]-4-(3-methoxyphenyl)piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Reactant | 1-[2-(Isochroman-1-yl)ethyl]-4-(2-methoxyphenyl)piperazine dihydrochloride monohydrate | HCID 23288951 | — |
| Product | 1-[2-(Isochroman-1-yl)ethyl]-4-(3-methoxyphenyl)piperazine dihydrochloride | HCID 23288913 | — |
Reaction Steps
Following the general procedure of EXAMPLE 1 and making non-critical variations but using 1-(3-methoxyphenyl)piperazine dihydrochloride (XI, 0.5173 g, 1.95 mmol) in place of 1-(2-chlorophenyl)piperazine dihydrochloride (XI), the title compound is obtained (chromatography using methanol/dichloromethane, 1/99), mp 189.5-193°; MS (m/z) 352; IR (mineral oil) 2373, 1460, 1512, 1048, 748 and 1291 cm-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06133446 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-7f9604d87a1f4bbe9a08673fae53c277 |
| Source note | uspto-grants-2000_10 |