反应详情

Paratolylhydrazine hydrochloride (20 g) is added to a solution of 4-[(2-oxopropyl)thio]-1-(phenylmethyl)piperidine (33.2 g, prepared in Example 9) in isopropanol (150 ml) under nitrogen. After 30 minutes, the solution is cooled to 0° C. and saturated with gaseous hydrogen chloride. After 4 hours at room temperature, the precipitate formed is filtered off, washed with water and then taken up in hot ethanol. After cooling, the white crystals of 2,5-dimethyl-3-[[1-(phenylmethyl)piperidin-4-yl]thio]-1H-indole hydrochloride (28.3 g) are filtered off.

1. waitAfter 4 hours at room temperature
2. customthe precipitate formed
3. filtrationis filtered off
4. washwashed with water
5. temperatureAfter cooling
6. filtrationthe white crystals of 2,5-dimethyl-3-[[1-(phenylmethyl)piperidin-4-yl]thio]-1H-indole hydrochloride (28.3 g) are filtered off