2-(3,4-dihydro-1H-2-benzopyran-1-yl)acetic acid → (+)-1-[2-(Isochroman-1-yl)ethyl]-4-(4-methoxyphenyl)piperazine dihydrochloride

Participants

Reaction Steps

Following the general procedure of EXAMPLE 48 and making non-critical variations but using (+)-(isochroman-1-yl)acetic acid (prepared in the same manner as for EXAMPLE 45, Step 3, but using S-(-)-α-methylbenzylamine in place of R-(+)-α-methylbenzylamine), containing some (-)-(isochroman-1-yl)acetic acid as an impurity, in place of (-)-(isochroman-1-yl)acetic acid (LXI, EXAMPLE 45--Step 3), and using 1-(4-methoxyphenyl)piperazine dihydrochloride (XI) in place of 4-(piperazin-1-yl)benzamide (IV), the title compound is obtained, mp 210-216°; [α]+42 (c 0.99, CH2Cl2).

Provenance & Evidence