HuagongsheHuagongshe Chemistry Print Report · For research reference only
(6-Bromoisochroman-1-yl)acetic acid → 1-(4-Fluorophenyl)-4-[2-(6-bromoisochroman-1-yl)ethyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (6-Bromoisochroman-1-yl)acetic acid | HCID 10540012 | — |
| Reactant | 1-[2-(Isochroman-1-yl)ethyl]-4-(2-methoxyphenyl)piperazine dihydrochloride monohydrate | HCID 23288951 | — |
| Reactant | 1-(4-Fluorophenyl)-4-[2-(6-bromoisochroman-1-yl)]acetyl piperazine | HCID 53887313 | — |
| Product | 1-(4-Fluorophenyl)-4-[2-(6-bromoisochroman-1-yl)ethyl]piperazine | HCID 15487836 | — |
Reaction Steps
(6-Bromoisochroman-1-yl)acetic acid (EXAMPLE 22, LXVIII) is coupled with 4-fluorophenylpiperazine (XI) and the resulting amide, 1-(4-fluorophenyl)-4-[2-(6-bromoisochroman-1-yl)]acetyl piperazine (LXIII, 1.64 mmol) is reduced following the general procedure of EXAMPLE 50 and making non-critical variations, to give the title compound, HRMS Calcd for C21H24N2O1Br1F1 =418.1056, found=418.1057.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06133446 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-55edd768040a4ec48db052cc606d8b04 |
| Source note | uspto-grants-2000_10 |