HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzenesulfonamide → (S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]-cis-3,5-dimethylpiperazin-1-yl]benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzenesulfonamide | HCID 120231 | — |
| Reactant | 4-(Piperazin-1-yl)benzene-1-sulfonamide | HCID 901897 | — |
| Reactant | rel-(2R,6S)-2,6-dimethylpiperazine | HCID 6950261 | — |
| Reactant | 4-(3,5-Dimethylpiperazin-1-yl)benzenesulfonamide | HCID 23288831 | — |
| Reactant | 1-(2-Chloroethyl)-4-methyl-isochroman | HCID 23288938 | — |
| Reactant | (4S)-4-(phenylmethyl)-3-(2-phenylpropionyl)-2-oxazolidinone | HCID 56980759 | — |
| Product | (S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]-cis-3,5-dimethylpiperazin-1-yl]benzenesulfonamide | HCID 21308103 | — |
Reaction Steps
Following the general procedure of EXAMPLE 49 and making non-critical variations 2-(isochroman-1-yl)ethanol-O-methanesulfonate (LXXX, 0.412 g) and 4-(3,5-dimethylpiperazin-1-yl)benzenesulfonamide [(IV), 0.433 g; prepared from 4-fluorobenzenesulfonamide, III, and cis-2,6-dimethylpiperazine, II (Aldrich), by the method of EXAMPLE 47] gives the title compound; mp 170-175 (decomp)°; MS (m/z) 429; IR (mineral oil) 1153, 1596, 1325, 1162 and 1096 cm-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06133446 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-7e93ca9197244dd48f8f4e64ea4022a5 |
| Source note | uspto-grants-2000_10 |