HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Piperazin-1-yl)benzene-1-sulfonamide → 4-[4-((R)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Piperazin-1-yl)benzene-1-sulfonamide | HCID 901897 | — |
| Reactant | (-)-2-(Isochroman-1-yl)ethanol | HCID 14141298 | — |
| Product | 4-[4-((R)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]-benzenesulfonamide | HCID 10811059 | — |
Reaction Steps
Following the general procedure of EXAMPLE 49 and making non-critical variations 2-(isochroman-1-yl)ethanol (LXXIX, (+)-enantiomer, 0.6045 g) and 4-(piperazin-1-yl)benzenesulfonamide (IV, 0.9824 g) are combined to give the title compound, mp 189-190°; MS (m/z) 401; [α]D +48 (c 0.877, DMF); IR (mineral oil) 1662, 1594, 1150, 1101, 614 cm-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06133446 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-67c5e8aca1214ce6ae6cd55953054aed |
| Source note | uspto-grants-2000_10 |