Dichloromethane → HCID 23284535, compound

Participants

Reaction Steps

Pyridinium chlorochromate (20.0 g, 93 mmol) was added to a dichloromethane (200 ml) solution of 2-chloro-α-cyclohexyl-3-pyridinemethanol (17.0 g, 75 mmol), and the mixture was stirred at room temperature for 4 hours. The reaction solution was mixed with pyridinium chlorochromate (10.0 g, 46 mmol) and stirred for 2 hours at room temperature, and then ether was added to the reaction solution to remove insoluble matter by filtration. The solvent was evaporated under a reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane-chloroform) to give 2-chloro-3-cyclohexylcarbonylpyridine (14.9 g, 88%) as an oily material.

Provenance & Evidence