HCID 23284530, compound → (2-Chloropyridin-3-yl)(thiophen-2-yl)methanone

Participants

Reaction Steps

To a toluene (100 ml) solution of α-(2-chloropyridin-3-yl)-2-thiophenmethanol (6.14 g, 27.2 mmol) was added 85% manganese dioxide (25 g, 245 mmol), followed by 2 hours of heating under reflux. The reaction solution was passed through celite and the resulting filtrate was concentrated under a reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane-chloroform) to give 2-chloro-3-(2-thiophenecarbonyl)pyridine (5.32 g, 23.8 mmol, 87%).

Provenance & Evidence