HCID 12721727, compound → HCID 23284540, compound

Participants

Reaction Steps

α-(3-Chlorobenzoyl)acetamide (19.76 g, 0.1 mol) was dissolved in 250 ml of ethanol, and the solution was mixed with 19.15 g (0.11 mol) of 1,1-diethoxy-3-pentanone and heated under reflux for 40 hours. After cooling to room temperature, the reaction solution was poured into ice water and extracted with chloroform. The organic layer was washed with 1 N hydrochloric acid, brine and dried over anhydrous magnesium sulfate, magnesium sulfate was removed by filtration and then the resulting filtrate was concentrated under a reduced pressure. Thereafter, the resulting residue was mixed with diethyl ether and the thus formed crystals were collected by filtration and washed with diethyl ether to give 18.50 g of 3-(3-chlorobenzoyl)-6-ethyl-2-pyridone in the form of crystals. The yield was 71%.

Provenance & Evidence