4-(3-chlorophenyl)-1-ethyl-7-(1-hydroxyethyl)pyrido[2,3-d]pyrimidin-2(1H)-one → HCID 23284488, compound

Participants

Reaction Steps

Manganese dioxide (1.00 g) was added to a solution of 366 mg (1.1 mmol) of 4-(3-chlorophenyl)-1-ethyl-7-(1-hydroxyethyl)pyrido[2,3-d]pyrimidin-2(1H)-one dissolved in 20 ml of chloroform, and the mixture was heated under reflux for 1 hour. The reaction solution was mixed with 1.00 g of manganese dioxide and heated under reflux for 1 hour and then again mixed with 500 mg of manganese dioxide and heated under reflux for 1 hour. After removing insoluble matter by filtration, the filtrate was concentrated under a reduced pressure and the resulting residue was purified by silica gel column chromatography (hexane-ethyl acetate-chloroform) to give 303 mg of 7-acetyl-4-(3-chlorophenyl)-1-ethylpyrido[2,3-d]pyrimidin-2(1H)-one. The yield was 84%.

Provenance & Evidence