Hydrochloric Acid → 4-(3-chlorophenyl)-1-ethyl-7-(1-hydroxyethyl)pyrido[2,3-d]pyrimidin-2(1H)-one

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Reaction Steps

Methanol (30 ml) and 30 ml of 1 N sodium hydroxide aqueous solution were added to 6.78 g (18.2 mmol) of 7-(1-acetoxyethyl)-4-(3-chlorophenyl)-1-ethylpyrido[2,3-d]pyrimidin-2(1H)-one, followed by stirring for 20 minutes at room temperature. The reaction solution was neutralized by adding 1 N hydrochloric acid and extracted with chloroform. The organic layer was washed with brine and dried over anhydrous magnesium sulfate, magnesium sulfate was removed by filtration and the resulting filtrate was concentrated under a reduced pressure. Thereafter, the resulting residue was purified by silica gel column chromatography (chloroform) to give 4.50 g of 4-(3-chlorophenyl)-1-ethyl-7-(1-hydroxyethyl)pyrido[2,3-d]pyrimidin-2(1H)-one in the form of crystals. The yield was 75%.

Provenance & Evidence