Hydrogen Bromide → 8-Bromo-1,7-naphthyridin-6-amine

Beteiligte Stoffe

Reaktionsschritte

Through a stirred solution of 2-Cyano-3-pyridylacetonitrile (3.6 g, 0.025 mol) in toluene (80 ml) is bubbled HBr for 5 h. Then, 4N NaOH is carefully added and the suspension stirred vigorously. The mixture is filtered and the product washed with water and dried. Crystallisation from toluene affords the title compound. Mass M+H 225. Melting point 188° C., decomposition.

Herkunft & Nachweise