反应详情

温度

70 °C

To a solution of 6-amino-8-(3-nitrophenyl)-1,7-naphthyridine (500 mg, 1.87 mmol; prepared according to example 1) in concentrated sulfuric acid and water (3 ml, 2:1) is added sodium nitrate (155 mg, 2.25 mmol) at 4° C. After 30 minutes, the ice bath is removed, and the mixture is warmed to 70° C. for 30 minutes. the reaction mixture is poured onto ice, and the solution is neutralized by adding sodium bicarbonate. The precipitate is filtered and washed with water affording the title compound. mp 262-265° C.

1. customthe ice bath is removed
2. additionthe reaction mixture is poured onto ice
3. additionby adding sodium bicarbonate
4. filtrationThe precipitate is filtered
5. washwashed with water affording the title compound