Potassium Hydroxide → 6-Ethynyl-8-(3-nitrophenyl)-1,7-naphthyridine

Participants

Reaction Steps

To a solution of 6-trimethylsilylethynyl-8-(3-nitrophenyl)-1,7-naphthyridine (77 mg, 0.22 mmol) in methanol (0.5 ml) and toluene (0.5 ml) is added 1N potassium hydroxide (0.22 ml). The mixture was stirred for 2 h. The suspension is filtered and the product washed with water and ether affording the title compound. Mass M+H 276; mp 215° C. decomposition.

Provenance & Evidence