3-Chloro-6-(4-cyanophenyl)-4-(ethoxycarbonyl)-pyridazine → 3-Chloro-6-(4-cyanophenyl)pyridazine

HRID 36904Notes

Reaction equation

HRID 36904 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5]([C:13]2[CH:18]=[CH:17][C:16]([C:19]#[N:20])=[CH:15][CH:14]=2)=[CH:6][C:7]=1C(OCC)=O>O>[Cl:1][C:2]1[N:3]=[N:4][C:5]([C:13]2[CH:18]=[CH:17][C:16]([C:19]#[N:20])=[CH:15][CH:14]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 194198173-Chloro-6-(4-cyanophenyl)-4-(ethoxycarbonyl)-pyridazine

Product 1

HCID 64052563-Chloro-6-(4-cyanophenyl)pyridazine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3-chloro-6-(4-cyanophenyl)-4-(ethoxycarbonyl)-pyridazine After the reaction solution has been stirred into water the aqueous phase is extracted with ethyl acetate. The organic phase is dried, evaporated down and the residue is chromatographed. Rf value: 0.37 (silica gel; cyclohexane/ethyl acetate=2:1)

Workup

  1. extractionis extracted with ethyl acetate
  2. customThe organic phase is dried
  3. customevaporated down
  4. customthe residue is chromatographed

Sources & evidence

ORD record
ord-1a1e125036304882b14d2102b2a17ade
Source dataset
uspto-grants-1995_05
Patent number
US05418233

Reaction notes

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