HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → HCID 15307268, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 3-Hydroxyestra-1,3,5(10),6-tetraen-17-one | HCID 102225 | — |
| Solvent | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 15307268 | HCID 15307268 | — |
Reaction Steps
A suspension of 2.6 g of 3-hydroxy-estra-1,3,5(10),6-tetraen-17-one in 26 ml of tetrahydrofuran and 2.6 ml of dihydropyran is stirred with 12.3 mg of para-toluenesulfonic acid for 3 hours at room temperature. Then, it is diluted with ethyl acetate, washed with sodium bicarbonate solution as well as with saturated sodium chloride solution, dried on sodium sulfate and concentrated by evaporation in a vacuum. 3.0 g of 3-tetrahydropyranyloxy-estra-1,3,5(10),6-tetraen-17-one is obtained as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06136800 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-81ce56f962214315aba1bd3595401140 |
| Source note | uspto-grants-2000_10 |