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Potassium Carbonate → (S)-N-benzylidene-1-[1-(7-bromo-1,4-benzodioxan-2-ylmethyl)-4-piperidyl]methylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | N-Benzylidene(piperidin-4-yl)methanamine | HCID 11820173 | — |
| 反応物 | (R)-7-bromo-1,4-benzodioxan-2-ylmethyl 4-toluenesulphonate | HCID 54071671 | — |
| 触媒 | Potassium Iodide | HCID 4875 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | (S)-N-benzylidene-1-[1-(7-bromo-1,4-benzodioxan-2-ylmethyl)-4-piperidyl]methylamine | HCID 54401525 | — |
反応手順
A mixture of (R)-7-bromo-1,4-benzodioxan-2-ylmethyl 4-toluenesulphonate (6.5 g, prepared as described in WO97/03071), N-benzylidene-4-piperidylmethylamine (3.0 g), potassium carbonate (4.1 g), and potassium iodide (10 mg) in acetonitrile (200 ml) was heated at reflux, with stirring, under nitrogen for 24 hours. The reaction was cooled, filtered and concentrated under reduced pressure to afford (S)-N-benzylidene-1-[1-(7-bromo-1,4-benzodioxan-2-ylmethyl)-4-piperidyl]methylamine (6.3 g) as an orange-brown viscous oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06136825 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-92f1ff4b8956456084127daf68f79825 |
| 出典メモ | uspto-grants-2000_10 |