4-Hydrazinylbenzenesulfonamide hydrochloride → HCID 23285390, compound

HRID 369089Notes

Reaction equation

HRID 369089 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10](=O)[CH2:11][C:12](=O)[CH:13]([F:15])[F:14].Cl.[S:19]([C:23]1[CH:28]=[CH:27][C:26]([NH:29][NH2:30])=[CH:25][CH:24]=1)(=[O:22])(=[O:21])[NH2:20]>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[N:29]([C:26]2[CH:25]=[CH:24][C:23]([S:19]([NH2:20])(=[O:22])=[O:21])=[CH:28][CH:27]=2)[N:30]=[C:12]([CH:13]([F:15])[F:14])[CH:11]=1

Participants

3

Reactant 2

HCID 27945674-Hydrazinylbenzenesulfonamide hydrochlorideHCID 23285405HCID 23285405, compound

Product 1

HCID 23285390HCID 23285390, compoundYield 37%

Procedure

The procedure of Example 9 was repeated using 1-(benzothiazol-2-yl)-4,4-difluorobutane-1,3-dione and 4-sulfamoylphenylhydrazine hydrochloride as the starting materials to obtain 4-[5-(benzothiazol-2-yl)-3-difluoromethyl-1H-pyrazol-1-yl]benzenesulfonamide (yield, 37%). NMR(CDCl3 -DMSO-d6) δ: 6.86 (1H, t, J=54.5 Hz), 7.12 (2H, s), 7.25 (1H, s), 7.43-7.66 (4H, m), 7.92-8.06 (4H, m); mp 247-249° C. (DMF-ethanol)

Sources & evidence

ORD record
ord-22f0266cd7364c98bb6fb395abbc7f7f
Source dataset
uspto-grants-2000_10
Patent number
US06136831

Reaction notes

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