4-Hydrazinylbenzenesulfonamide hydrochloride → HCID 23285403, compound

HRID 369097Notes

Reaction equation

HRID 369097 reaction equation
[CH3:1][C:2]1[C:10]2[S:9][C:8]([C:11](=O)[CH2:12][C:13](=O)[CH:14]([F:16])[F:15])=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.Cl.[S:20]([C:24]1[CH:29]=[CH:28][C:27]([NH:30][NH2:31])=[CH:26][CH:25]=1)(=[O:23])(=[O:22])[NH2:21]>>[F:15][CH:14]([F:16])[C:13]1[CH:12]=[C:11]([C:8]2[S:9][C:10]3[C:2]([CH3:1])=[CH:3][CH:4]=[CH:5][C:6]=3[N:7]=2)[N:30]([C:27]2[CH:26]=[CH:25][C:24]([S:20]([NH2:21])(=[O:23])=[O:22])=[CH:29][CH:28]=2)[N:31]=1

Participants

3

Reactant 2

HCID 27945674-Hydrazinylbenzenesulfonamide hydrochlorideHCID 23285435HCID 23285435, compound

Product 1

HCID 23285403HCID 23285403, compound

Procedure

The procedure of Example 9 was repeated using 1-(7-methylbenzothiazol-2-yl)-4,4-difluorobutane-1,3-dione and 4-sulfamoylphenylhydrazine hydrochloride as the starting materials to obtain 4-[3-difluoromethyl-5-(7-methylbenzothiazol-2-yl)-1H-pyrazol-1-yl]benzenesulfonamide. NMR(DMSO-d6) δ: 2.54 (3H, s), 7.23 (1H, t, J=54.1 Hz), 7.34-7.57 (5H, m), 7.75-7.78 (3H, m), 7.94 (2H, d, J=8.6 Hz); mp 264-265° C. (ethyl acetate-ethanol)

Sources & evidence

ORD record
ord-434f561379d9437c99c03625cbbb5f86
Source dataset
uspto-grants-2000_10
Patent number
US06136831

Reaction notes

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