4-(Methylsulfonyl)phenylhydrazine hydrochloride → HCID 178504789, compound

HRID 369101Notes

Reaction equation

HRID 369101 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:9][C:8]([C:10](=O)[CH2:11][C:12](=O)[C:13]([F:16])([F:15])[F:14])=[N:7][C:6]=2[CH:19]=1.Cl.[CH3:21][S:22]([C:25]1[CH:30]=[CH:29][C:28]([NH:31][NH2:32])=[CH:27][CH:26]=1)(=[O:24])=[O:23]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:9][C:8]([C:10]3[N:31]([C:28]4[CH:27]=[CH:26][C:25]([S:22]([CH3:21])(=[O:24])=[O:23])=[CH:30][CH:29]=4)[N:32]=[C:12]([C:13]([F:16])([F:15])[F:14])[CH:11]=3)=[N:7][C:6]=2[CH:19]=1

Participants

3

Reactant 2

HCID 27351814-(Methylsulfonyl)phenylhydrazine hydrochlorideHCID 178520890HCID 178520890, compound

Product 1

HCID 178504789HCID 178504789, compoundYield 25%

Procedure

The procedure of Example 9 was repeated using 1-(6-fluorobenzimidazol-2-yl)-4,4,4-trifluorobutane-1,3-dione and 4-methylsulfonylphenylhydrazine hydrochloride as the starting materials to obtain 6-fluoro-2-[1-(4-methylsulfonylphenyl)-3-trifluoromethyl-1H-pyrazol-5-yl]benzimidazole (yield, 25%).

Sources & evidence

ORD record
ord-65587843f5ba4e6eadc790389ce94cdd
Source dataset
uspto-grants-2000_10
Patent number
US06136831

Reaction notes

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