5-Fluoro-2-nitrophenol → 2-Amino-5-fluorophenol

Participants

Reaction Steps

To 50 ml of ethanol was added 5-fluoro-2-nitrophenol (7.86 g, 50 mmol) and 10% Pd/C (0.786 g) and the mixture was stirred under a hydrogen stream for 3 hours at room temperature. Then the reaction mixture was filtered and the filtrate concentrated. The residue was subjected to recrystallization from toluene to afford 2-amino-5-fluoro-phenol (5.52 g, yield: 87%).

Provenance & Evidence