Isobutylbenzene → Ethyl 4-iso-butylbenzoylformate

HRID 369131Notes

Reaction equation

HRID 369131 reaction equation
[CH2:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].C1(C2C=CC([C:21]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[O:22])=CC=2)C=CC=CC=1>>[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:21]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[O:22])=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 10870IsobutylbenzeneHCID 80389Ethyl 4-phenylbenzoylformate

Product 1

HCID 12585534Ethyl 4-iso-butylbenzoylformateYield 81%

Procedure

A mixture of 27 g (200 mmol) of isobutylbenzene and 24 mL (215 mmol) of ethyl oxalylchloride underwent Friedel-Crafts acylation reaction in an analogous fashion as described for the synthesis of ethyl 4-phenylbenzoylformate to yield 38 g (81% yield) of ethyl 4-isobutylbenzoylformate as a colorless oil.

Workup

  1. customacylation reaction in an analogous fashion

Sources & evidence

ORD record
ord-3d0b4a89121f4fb5b95a5fc6cb9af947
Source dataset
uspto-grants-2000_10
Patent number
US06136832

Reaction notes

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