反应详情

温度

-78 °C

1.48 g (3.95 mmol) of the compound from Example 5 are dissolved in 30 ml of toluene, the solution is cooled to -78° C. under nitrogen and 6.6 ml (10 mmol) of a 1.5 molar solution of diisobutylaluminium hydride in toluene are added dropwise at this temperature. The cooling bath is removed and the mixture is stirred at room temperature for 2 h. After hydrolysis using 20% strength aqueous potassium sodium tartrate solution, the organic phase is separated off, the aqueous phase is washed three times with toluene, and the combined organic phases are washed with saturated sodium chloride solution and dried using sodium sulphate.

1. customThe cooling bath is removed
2. customAfter hydrolysis
3. customthe organic phase is separated off
4. washthe aqueous phase is washed three times with toluene
5. washthe combined organic phases are washed with saturated sodium chloride solution
6. customdried