(4-Methoxyphenyl)boronic acid → HCID 53688502, compound

Participants

Reaction Steps

The operation is carried out as in Stage 1 of Example 10 using 4-methoxy benzeneboronic acid instead of thiophene-2-boronic acid, starting with 351.6 mg of methyl ester of N-[(1,1-dimethylethoxy) carbonyl]-O-[(trifluoromethyl) sulphonyl]-L-tyrosine (prepared as indicated in Stage 1 of Example 10), 10 ml of toluene, 250 mg of 4-methoxybenzene boronic acid, 170.3 mg of potassium bicarbonate and 190.17 mg of 5-tetrakis (triphenyl phosphine) Pd(O). In this way 199 mg of expected product is obtained.

Provenance & Evidence