Hydrochloric Acid → HCID 484058, compound

Participants

Reaction Steps

Concentrated hydrochloric acid (2 ml) was added to ethyl 7-amino-1-(5-tert-butoxycarbonylamino-2,4-difluorophenyl)-6-fluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate (170 mg), and the mixture was heated under reflux for 5 hours. After the reaction mixture was cooled back to room temperature, water (2 ml) was added thereto. Solids deposited were collected by filtration and then washed successively with water, ethanol and diethyl ether to obtain the title compound (68 mg) as a pale yellow powder.

Provenance & Evidence