Methylamine → HCID 23284692, compound

Participants

Reaction Conditions

Reaction Steps

1-(5-Amino-2,4-difluorophenyl)-6,7-difluoro-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (200 mg) and a 40% aqueous solution (210 mg) of methylamine were added to pyridine (1 ml), and the mixture was heated and stirred overnight at 60° C. After the reaction mixture was allowed to cool, the solvent was distilled off under reduced pressure. Ethanol was added to the residue to collect solids. The solids were washed successively with ethanol and diethyl ether to obtain the title compound (115 mg) as a colorless powder.

Provenance & Evidence