Pyridine → HCID 23284825, compound

Participants

Reaction Steps

A 40% aqueous solution (100 mg) of methylamine and 1-(5-amino-2-chloro-4-fluorophenyl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (100 mg) were added to pyridine (2 ml), and the mixture was stirred at room temperature for 2 hours. After the solvent was distilled off under reduced pressure, ethanol was added to the residue, and solids were collected by filtration to obtain the title compound (46 mg) as pale yellow crystals.

Provenance & Evidence