Ammonia → HCID 23284818, compound

Participants

Reaction Conditions

Reaction Steps

1-(5-Amino-2,4-difluorophenyl)-7-fluoro-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (70 mg) was added to a mixed liquid of 28% aqueous ammonia (85 mg) and pyridine (2 ml), and the mixture was stirred at 50° C. for 15 hours. The reaction mixture was acidified with 3% citric acid (20 ml), and solids formed were collected by filtration. The solids were subjected to azeotropic distillation with ethanol and toluene. Hexane was added to the residue to conduct filtration, thereby obtain the title compound (50 mg) as a yellow powder.

Provenance & Evidence