Methylamine → HCID 23284821, compound

Participants

Reaction Steps

8-Chloro-6,7-difluoro-1-(2,4-difluoro-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (200 mg) and an aqueous solution (about 40%; 550 mg) of methylamine were added to pyridine (1,200 mg), and the mixture was stirred at room temperature for 21 hours. The reaction mixture was concentrated under reduced pressure, and ethanol (1 ml) was added to the residue. Deposits were collected by filtration and washed with ethanol and diisopropyl ether in that order to obtain the title compound (173 mg) as a pale brown powder.

Provenance & Evidence