Hydrogen Bromide → HCID 23284706, compound

Participants

Reaction Steps

Ethyl 1-(2,4-difluoro-5-methoxyphenyl)-6,7-difluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate (2.32 g) was added to a mixed liquid (1:1, v/v; 30 ml) of 47% hydrobromic acid and acetic acid, and the mixture was stirred and refluxed for 44 hours. After distilled water (20 ml) was added to the reaction mixture, it was allowed to cool. Deposits were collected by filtration and washed with ethanol and diisopropyl ether in that order to obtain the title compound (1.37 g) as a colorless powder.

Provenance & Evidence