Ethanolamine → HCID 69958994, compound

Participants

Reaction Conditions

Reaction Steps

1-(6-Amino-3,5-difluoropyridin-2-yl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (300 mg) and ethanolamine (300 mg) were added to pyridine (1,300 mg), and the mixture was stirred at 50° C. for 2.5 hours. The reaction mixture was concentrated under reduced pressure. A process of adding ethanol (2 ml) to the residue and then concentrating the mixture under reduced pressure was conducted twice repeatedly. Ethanol (4 ml) was added to the resultant residue, and deposits were collected by filtration and washed with ethanol and diisopropyl ether in that order to obtain the title compound (290 mg) as a colorless powder.

Provenance & Evidence